After 50 years of Peter Parker as Spider-Man,his archest of nemeses is taking over as Marvel Comics' most iconic superhero.

Out today, the landmark Amazing Spider-ManNo. 700 features a final battle between the mind-swapped Parker and Dr. Otto Octavius — aka the evil Doctor Octopus — resulting in the hero suffering a possibly permanent defeat and Doc Ock standing victorious in the mind and body of Spider-Man.